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retinal pigment epithelium cell line arpe 19  (ATCC)


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    ATCC retinal pigment epithelium cell line arpe 19
    ceRNA networks, drug-gene interactions and PCR validation. (A) The ceRNA-regulating networks illustrate protein-coding genes (red circles), miRNAs (blue diamonds) and lncRNAs (green hexagons), with black lines indicating interactions among lncRNA, miRNA and mRNA, where ceRNA refers to ceRNAs. (B) Validation through reverse transcription-quantitative PCR analysis confirms that CDKN2A and IDH2 expression levels are significantly higher in Y79 cells compared <t>to</t> <t>ARPE-19</t> cells. Data were normalized to GAPDH expression using the 2 −ΔΔCq method, with each experiment performed in triplicate. ***P<0.001 and ****P<0.0001. (C) The drug-gene interaction analysis shows the linkage map of two hub genes, CDKN2A and IDH2 , along with their potential target drugs, including bisphenol A (code: C006780), sodium arsenite (code: C017947), docetaxel (code: D000077143) and hexabromocyclododecane (code: C089796). ceRNA, competing endogenous RNAs; miRNA, microRNA; lncRNA, long non-coding RNA; RB, retinoblastoma.
    Retinal Pigment Epithelium Cell Line Arpe 19, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 4476 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/retinal+pigment+epithelium+cell+line+arpe+19/ARPE-19/pmc13100569-72-2-19
    Average 99 stars, based on 4476 article reviews
    retinal pigment epithelium cell line arpe 19 - by Bioz Stars, 2026-10
    99/100 stars

    Images

    1) Product Images from "Exploring multiple biomarkers and constructing ferroptosis-associated competing endogenous RNA networks as dual targets in retinoblastoma"

    Article Title: Exploring multiple biomarkers and constructing ferroptosis-associated competing endogenous RNA networks as dual targets in retinoblastoma

    Journal: Oncology Letters

    doi: 10.3892/ol.2026.15582

    ceRNA networks, drug-gene interactions and PCR validation. (A) The ceRNA-regulating networks illustrate protein-coding genes (red circles), miRNAs (blue diamonds) and lncRNAs (green hexagons), with black lines indicating interactions among lncRNA, miRNA and mRNA, where ceRNA refers to ceRNAs. (B) Validation through reverse transcription-quantitative PCR analysis confirms that CDKN2A and IDH2 expression levels are significantly higher in Y79 cells compared to ARPE-19 cells. Data were normalized to GAPDH expression using the 2 −ΔΔCq method, with each experiment performed in triplicate. ***P<0.001 and ****P<0.0001. (C) The drug-gene interaction analysis shows the linkage map of two hub genes, CDKN2A and IDH2 , along with their potential target drugs, including bisphenol A (code: C006780), sodium arsenite (code: C017947), docetaxel (code: D000077143) and hexabromocyclododecane (code: C089796). ceRNA, competing endogenous RNAs; miRNA, microRNA; lncRNA, long non-coding RNA; RB, retinoblastoma.
    Figure Legend Snippet: ceRNA networks, drug-gene interactions and PCR validation. (A) The ceRNA-regulating networks illustrate protein-coding genes (red circles), miRNAs (blue diamonds) and lncRNAs (green hexagons), with black lines indicating interactions among lncRNA, miRNA and mRNA, where ceRNA refers to ceRNAs. (B) Validation through reverse transcription-quantitative PCR analysis confirms that CDKN2A and IDH2 expression levels are significantly higher in Y79 cells compared to ARPE-19 cells. Data were normalized to GAPDH expression using the 2 −ΔΔCq method, with each experiment performed in triplicate. ***P<0.001 and ****P<0.0001. (C) The drug-gene interaction analysis shows the linkage map of two hub genes, CDKN2A and IDH2 , along with their potential target drugs, including bisphenol A (code: C006780), sodium arsenite (code: C017947), docetaxel (code: D000077143) and hexabromocyclododecane (code: C089796). ceRNA, competing endogenous RNAs; miRNA, microRNA; lncRNA, long non-coding RNA; RB, retinoblastoma.

    Techniques Used: Biomarker Discovery, Reverse Transcription, Real-time Polymerase Chain Reaction, Expressing

    Related Articles

    Cell Culture:

    Article Title: Physcion 8-O-β-glucopyranoside exerts protective roles in high glucose-induced diabetic retinopathy via regulating lncRNA NORAD/miR-125/STAT3 signalling.
    Article Snippet: .. The human retinal pigment epithelium cell line ARPE-19 (ATCC, Mantissa, VA) was cultured in Dulbecco’s modified essential medium/Ham’s F12 medium (DMEM/F12, Gibco, Grand Island, NY) containing 10% heat-inactivated foetal bovine serum (FBS, Gibco), 100mg/mL of streptomycin, and 100U/mL of penicillin, and then maintained at 37 C in a humidified incubator with 5% CO2. ..

    Article Title: The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
    Article Snippet: .. The human retinal pigment epithelium cell line ARPE-19 (passage 19) was purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in a 1:1 mixture of Dulbecco’s modified Eagle’s medium (DMEM) and nutrient mixture F-12 (Life Technologies, Carlsbad, CA, USA). .. The medium was supplemented with 10% HyClone fetal bovine serum (FBS) (Thermo Fisher Scientific, Waltham, MA, USA), 100 U/mL of penicillin, 100 μg/mL of streptomycin (Lonza, Basel, Switzerland or Life Technologies, Carlsbad, CA, USA for both), and 2 mM of L-glutamine (Life Technologies, Carlsbad, CA, USA).

    Article Title: The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance.
    Article Snippet: .. The human retinal pigment epithelium cell line ARPE-19 (passage 19) was purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in a 1:1 mixture of Dulbecco’s modified Eagle’s medium (DMEM) and nutrient mixture F-12 (Life Technologies, Carlsbad, CA, USA). .. The medium was supplemented with 10% HyClone fetal bovine serum (FBS) (Thermo Fisher Scientific, Waltham, MA, USA), 100 U/mL of penicillin, 100 μg/mL of streptomycin (Lonza, Basel, Switzerland or Life Technologies, Carlsbad, CA, USA for both), and 2 mM of L-glutamine (Life Technologies, Carlsbad, CA, USA).

    Modification:

    Article Title: Physcion 8-O-β-glucopyranoside exerts protective roles in high glucose-induced diabetic retinopathy via regulating lncRNA NORAD/miR-125/STAT3 signalling.
    Article Snippet: .. The human retinal pigment epithelium cell line ARPE-19 (ATCC, Mantissa, VA) was cultured in Dulbecco’s modified essential medium/Ham’s F12 medium (DMEM/F12, Gibco, Grand Island, NY) containing 10% heat-inactivated foetal bovine serum (FBS, Gibco), 100mg/mL of streptomycin, and 100U/mL of penicillin, and then maintained at 37 C in a humidified incubator with 5% CO2. ..

    Article Title: The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
    Article Snippet: .. The human retinal pigment epithelium cell line ARPE-19 (passage 19) was purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in a 1:1 mixture of Dulbecco’s modified Eagle’s medium (DMEM) and nutrient mixture F-12 (Life Technologies, Carlsbad, CA, USA). .. The medium was supplemented with 10% HyClone fetal bovine serum (FBS) (Thermo Fisher Scientific, Waltham, MA, USA), 100 U/mL of penicillin, 100 μg/mL of streptomycin (Lonza, Basel, Switzerland or Life Technologies, Carlsbad, CA, USA for both), and 2 mM of L-glutamine (Life Technologies, Carlsbad, CA, USA).

    Article Title: The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance.
    Article Snippet: .. The human retinal pigment epithelium cell line ARPE-19 (passage 19) was purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in a 1:1 mixture of Dulbecco’s modified Eagle’s medium (DMEM) and nutrient mixture F-12 (Life Technologies, Carlsbad, CA, USA). .. The medium was supplemented with 10% HyClone fetal bovine serum (FBS) (Thermo Fisher Scientific, Waltham, MA, USA), 100 U/mL of penicillin, 100 μg/mL of streptomycin (Lonza, Basel, Switzerland or Life Technologies, Carlsbad, CA, USA for both), and 2 mM of L-glutamine (Life Technologies, Carlsbad, CA, USA).



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    Image Search Results


    ceRNA networks, drug-gene interactions and PCR validation. (A) The ceRNA-regulating networks illustrate protein-coding genes (red circles), miRNAs (blue diamonds) and lncRNAs (green hexagons), with black lines indicating interactions among lncRNA, miRNA and mRNA, where ceRNA refers to ceRNAs. (B) Validation through reverse transcription-quantitative PCR analysis confirms that CDKN2A and IDH2 expression levels are significantly higher in Y79 cells compared to ARPE-19 cells. Data were normalized to GAPDH expression using the 2 −ΔΔCq method, with each experiment performed in triplicate. ***P<0.001 and ****P<0.0001. (C) The drug-gene interaction analysis shows the linkage map of two hub genes, CDKN2A and IDH2 , along with their potential target drugs, including bisphenol A (code: C006780), sodium arsenite (code: C017947), docetaxel (code: D000077143) and hexabromocyclododecane (code: C089796). ceRNA, competing endogenous RNAs; miRNA, microRNA; lncRNA, long non-coding RNA; RB, retinoblastoma.

    Journal: Oncology Letters

    Article Title: Exploring multiple biomarkers and constructing ferroptosis-associated competing endogenous RNA networks as dual targets in retinoblastoma

    doi: 10.3892/ol.2026.15582

    Figure Lengend Snippet: ceRNA networks, drug-gene interactions and PCR validation. (A) The ceRNA-regulating networks illustrate protein-coding genes (red circles), miRNAs (blue diamonds) and lncRNAs (green hexagons), with black lines indicating interactions among lncRNA, miRNA and mRNA, where ceRNA refers to ceRNAs. (B) Validation through reverse transcription-quantitative PCR analysis confirms that CDKN2A and IDH2 expression levels are significantly higher in Y79 cells compared to ARPE-19 cells. Data were normalized to GAPDH expression using the 2 −ΔΔCq method, with each experiment performed in triplicate. ***P<0.001 and ****P<0.0001. (C) The drug-gene interaction analysis shows the linkage map of two hub genes, CDKN2A and IDH2 , along with their potential target drugs, including bisphenol A (code: C006780), sodium arsenite (code: C017947), docetaxel (code: D000077143) and hexabromocyclododecane (code: C089796). ceRNA, competing endogenous RNAs; miRNA, microRNA; lncRNA, long non-coding RNA; RB, retinoblastoma.

    Article Snippet: The human retinal pigment epithelium cell line ARPE-19 and the human RB cell line Y79 were sourced from the American Type Culture Collection.

    Techniques: Biomarker Discovery, Reverse Transcription, Real-time Polymerase Chain Reaction, Expressing